Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 9/20 | 0.51 |
| ▸ | PPARA | Q07869 | 9/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCND1 | P24385 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340675 | 1.00 | KDR (0.57) | KDRFFAR1PPARGPPARACCNB2 | |
| SCHEMBL6955816 | 0.92 | FFAR1 (0.61) | KDRFFAR1PPARGPPARAMAPT | |
| SCHEMBL6960376 | 0.91 | KDR (0.63) | KDRFFAR1PPARGPPARACCNB2 | |
| SCHEMBL6960372 | 0.91 | KDR (0.63) | KDRFFAR1PPARGPPARACCNB2 | |
| SCHEMBL7563293 | 0.90 | KDR (0.60) | KDRFFAR1PPARGPPARAPTPN2 | |
| SCHEMBL6957771 | 0.86 | FFAR1 (0.49) | KDRFFAR1PPARGPPARAMAPT | |
| SCHEMBL6957767 | 0.86 | FFAR1 (0.49) | KDRFFAR1PPARGPPARAMAPT | |
| SCHEMBL8139628 | 0.85 | KDR (0.53) | KDRFFAR1PPARGPPARAPTPN2 | |
| SCHEMBL8139624 | 0.85 | KDR (0.53) | KDRFFAR1PPARGPPARAPTPN2 | |
| SCHEMBL6584026 | 0.84 | KDR (0.47) | KDRFFAR1PPARGPPARAPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0783496-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996005186-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-22 | — | — | WO | disclosed |