Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173427 | 0.72 | BACE1 (0.36) | TDP1TSHRBACE1 | |
| SCHEMBL9026830 | 0.67 | TSHR (0.39) | TSHR | |
| SCHEMBL14354358 | 0.63 | TSHR (0.52) | TDP1TSHRBACE1 | |
| SCHEMBL7539674 | 0.59 | TSHR (0.42) | TDP1TSHRBACE1 | |
| SCHEMBL4205347 | 0.59 | BACE1 (0.38) | TDP1TSHRBACE1 | |
| SCHEMBL9808571 | 0.58 | TDP1 (0.41) | TDP1TSHRBACE1 | |
| SCHEMBL16695749 | 0.57 | TSHR (0.36) | TSHRBACE1 | |
| SCHEMBL6661321 | 0.57 | BACE1 (0.36) | TDP1TSHRBACE1 | |
| SCHEMBL30231638 | 0.56 | TSHR (0.39) | TDP1TSHRBACE1 | |
| SCHEMBL9402140 | 0.56 | MAPT (0.41) | TDP1TSHRBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919778-A | Cyclic amide derivatives | EISAI CO., LTD. (JP) | 1999-07-06 | — | — | US | disclosed |
| US-5654308-A | PREVENT OR TREAT DISEASE DUE TO INSUFFICIENT CHOLINE FUNCTION | EISAI CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| US-5620976-A | PREVENTION AND TREATMENT OF DISEASES DUE TO INSUFFICIENCY OF THE CENTRAL CHOLINE FUNCTIONS | EISAI CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0742216-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| US-5521182-A | ACETYLCHOLINESTERASE INHIBITORS | EISAI CO., LTD. (JP) | 1996-05-28 | — | — | US | disclosed |
| US-5504088-A | ACETYLCHOLINE ESTERASE INHIBITORS; ALZHEIMER'S DISEASE AND OTHER DISEASES CAUSED BY A LOW CONCENTRATION OF CHOLINE | EISAI CO., LTD. (JP) | 1996-04-02 | — | — | US | disclosed |
| EP-0677516-A1 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-5292735-A | Cyclic amide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0468187-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1992-01-29 | — | — | EP | disclosed |