Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 1/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gavestinel SCHEMBL678632 | 0.91 | GPR17 (1.00) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| Gavestinel SCHEMBL1721070 | 0.91 | GPR17 (1.00) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| Gavestinel SCHEMBL30184856 | 0.91 | GPR17 (1.00) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| Gavestinel SCHEMBL1995817 | 0.90 | GPR17 (0.98) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| Gavestinel SCHEMBL1995818 | 0.90 | GPR17 (0.98) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| Gavestinel SCHEMBL1995813 | 0.90 | GPR17 (0.98) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8344952 | 0.90 | KDM4E (0.83) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| SCHEMBL18623465 | 0.89 | GPR17 (0.73) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8784436 | 0.88 | GPR17 (0.71) | GPR17KDM4EMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8784426 | 0.88 | GPR17 (0.71) | GPR17KDM4EMEN1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919811-A | NEURODEGENERATIVE DISORDERS | GLAXO WELLCOME S.P.A. (IT) | 1999-07-06 | — | — | US | disclosed |