Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 11/20 | 0.64 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27265895 | 0.98 | HTR1B (0.62) | HTR1BNR2E1HTR1DSLC6A4HRH1 | |
| SCHEMBL17286559 | 0.91 | HTR1B (0.65) | HTR1BNR2E1HTR1DSLC6A4HRH1 | |
| SCHEMBL29802707 | 0.85 | HTT (0.53) | HTR1BNR2E1HTR1DMCHR1 | |
| SCHEMBL17912800 | 0.85 | HTT (0.51) | HTR1BNR2E1HTR1DSLC6A4HRH1 | |
| 1,2-Diisopentoxybenzene SCHEMBL2843498 | 0.82 | HTT (0.62) | MCHR1KDM4EALDH1A1 | |
| SCHEMBL5289923 | 0.82 | HTR1B (0.77) | HTR1BNR2E1HTR1DSLC6A4HRH1 | |
| SCHEMBL28717946 | 0.82 | HTR1B (0.61) | HTR1BNR2E1HTR1DSLC6A4HRH1 | |
| SCHEMBL29276738 | 0.82 | HTT (0.51) | HTR1BNR2E1HTR1DSLC6A4HRH1 | |
| SCHEMBL29829725 | 0.81 | NR2E1 (0.64) | HTR1BNR2E1HTR1DSLC6A4KDM4E | |
| SCHEMBL5031818 | 0.81 | NR2E1 (0.64) | HTR1BNR2E1HTR1DSLC6A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117063121-A | Photosensitive film, photosensitive element, and method for producing laminate | 株式会社力森诺科 | 2023-11-14 | — | — | CN | disclosed |
| US-11760752-B2 | Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760752-B2 | Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2023-09-19 | — | — | US | disclosed |
| US-20200299285-A1 | CARBOXYLIC ACID, ACYL SULFONAMIDE AND ACYL SULFAMIDE-DERIVATIZED BICYCLIC AZA-HETEROAROMATICS AS SELECTIVE MCL-1 INHIBITORS AND AS DUAL MCL-1/BCL-2 INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2020-09-24 | — | — | US | disclosed |
| CN-106137862-B | Composition and cosmetics containing nano Chinese angelica | 南京谷润生物科技有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-106137862-A | Composition containing nano Chinese angelica and cosmetics | 南京谷润生物科技有限公司 | 2016-11-23 | — | — | CN | disclosed |
| US-7205336-B2 | β-secretase inhibitors | MERCK & CO., INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205336-B2 | β-secretase inhibitors | MERCK & CO., INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2003099202-A2 | BETA-SECRETASE INHIBITORS | MERCK & CO., INC. (US) | 2003-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299285-A1 | CARBOXYLIC ACID, ACYL SULFONAMIDE AND ACYL SULFAMIDE-DERIVATIZED BICYCLIC AZA-HETEROAROMATICS AS SELECTIVE MCL-1 INHIBITORS AND AS DUAL MCL-1/BCL-2 INHIBITORS | MCL1, BCLAF1, BCL2A1 | HTR1B 2547/4885NR2E1 1489/4885HTR1D 2386/4885 |
| US-11760752-B2 | Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors | MCL1, BCLAF1, BCL2A1 | HTR1B 2547/4885NR2E1 1489/4885HTR1D 2386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.