Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 18/20 | 0.81 |
| ▸ | GSK3A | P49840 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345738 | 0.89 | GSK3B (1.00) | GSK3BGSK3A | |
| SCHEMBL30676716 | 0.86 | GSK3B (0.74) | GSK3BGSK3A | |
| SCHEMBL8344002 | 0.86 | GSK3B (0.74) | GSK3BGSK3AMAPT | |
| SCHEMBL8343916 | 0.84 | GSK3B (0.83) | GSK3BGSK3A | |
| SCHEMBL6071990 | 0.82 | GSK3B (0.75) | GSK3BGSK3A | |
| SCHEMBL6071982 | 0.82 | GSK3B (0.75) | GSK3BGSK3A | |
| SCHEMBL8344915 | 0.81 | GSK3B (0.82) | GSK3BGSK3A | |
| SCHEMBL6071654 | 0.81 | GSK3B (0.67) | GSK3BGSK3AMAPT | |
| SCHEMBL6071675 | 0.81 | GSK3B (0.67) | GSK3BGSK3AMAPT | |
| SCHEMBL8342510 | 0.80 | GSK3B (0.82) | GSK3BGSK3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009597-A2 | PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |