Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2891397 | 0.93 | ELANE (0.78) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8261194 | 0.93 | ELANE (0.72) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13872582 | 0.93 | ELANE (0.72) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13872623 | 0.93 | ELANE (0.72) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8261241 | 0.93 | ELANE (0.72) | ELANECYP2C9CYP3A4 | |
| SCHEMBL2897331 | 0.92 | ELANE (0.77) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8345068 | 0.91 | ELANE (0.72) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13412208 | 0.91 | ELANE (0.74) | ELANECYP2C9CYP3A4 | |
| SCHEMBL4547764 | 0.91 | ELANE (0.67) | ELANECYP2C9CYP3A4 | |
| SCHEMBL2896528 | 0.91 | ELANE (0.79) | ELANECYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546113-B1 | PYRIMIDINONE DERIVATIVES AS THERAPEUTIC AGENTS AGAINST ACUTE AND CHRONIC INFLAMMATORY, ISCHAEMIC AND REMODELLING PROCESSES | BAYER IP GMBH (DE) | 2013-05-01 | — | — | EP | disclosed |
| US-7687510-B2 | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes | BAYER HEALTHCARE AG (DE) | 2010-03-30 | — | — | US | disclosed |
| US-7687510-B2 | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes | BAYER HEALTHCARE AG (DE) | 2010-03-30 | — | — | US | disclosed |
| WO-2004024700-A1 | PYRIMIDINONE DERIVATIVES AS THERAPEUTIC AGENTS AGAINST ACUTE AND CHRONIC INFLAMMATORY, ISCHAEMIC AND REMODELLING PROCESSES | BAYER HEALTHCARE AG (DE) | 2004-03-25 | — | — | WO | disclosed |