SCHEMBL8347283

SCHEMBL8347283

CON=C(C(=O)OC)c1cccc(Cl)c1COc1cc(C(F)(F)F)nc(OC(C)C)n1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.41
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36
KDM4E B2RXH2 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
ATM Q13315 1/20 0.35
NR1H4 Q96RI1 3/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C19 P33261 1/20 0.34
P2RX7 Q99572 3/20 0.33
PTGES O14684 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8352547 0.92 PTGS1 (0.35) HIF1APTGS1PTGS2KDM4ENPSR1
SCHEMBL8347644 0.78 PTGS1 (0.37) HIF1APTGS1PTGS2KDM4ENPSR1
SCHEMBL5999116 0.76 HIF1A (0.38) HIF1APTGS1PTGS2CYP1A2
SCHEMBL5997735 0.75 HIF1A (0.39) HIF1APTGS1PTGS2CYP1A2
SCHEMBL5998920 0.74 HIF1A (0.38) HIF1APTGS1PTGS2CYP1A2
SCHEMBL5997731 0.74 HIF1A (0.38) HIF1APTGS1PTGS2CYP1A2
Fluacrypyrim SCHEMBL5997532 0.73 HIF1A (0.37) HIF1APTGS1PTGS2CYP1A2
Fluacrypyrim SCHEMBL29413955 0.73 HIF1A (0.37) HIF1APTGS1PTGS2CYP1A2
Fluacrypyrim SCHEMBL682688 0.73 HIF1A (0.37) HIF1APTGS1PTGS2CYP1A2
Fluacrypyrim SCHEMBL83958 0.73 HIF1A (0.37) HIF1APTGS1PTGS2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5935965-A PESTICIDES, FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 1999-08-10 US disclosed