Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12963503 | 0.90 | IGF1R (0.57) | IGF1RMAPK1KDRPLK4CHEK1 | |
| SCHEMBL1116446 | 0.88 | IGF1R (0.73) | IGF1RMAPK1KDRPLK4CHEK1 | |
| SCHEMBL12933420 | 0.86 | IGF1R (0.56) | IGF1RMAPK1KDRPLK4CHEK1 | |
| SCHEMBL12963504 | 0.84 | IGF1R (0.57) | IGF1RMAPK1KDRPLK4CHEK1 | |
| SCHEMBL301341 | 0.82 | MAPT (0.76) | IGF1RMAPK1KDRCHEK1AURKA | |
| SCHEMBL6976835 | 0.82 | IGF1R (0.78) | IGF1RMAPK1KDRPLK4CHEK1 | |
| SCHEMBL27982093 | 0.81 | SYK (0.63) | IGF1RMAPK1KDRPLK4CHEK1 | |
| SCHEMBL301779 | 0.81 | EGFR (0.78) | IGF1RMAPK1KDRROCK2ROCK1 | |
| SCHEMBL1116424 | 0.79 | EGFR (0.83) | IGF1RMAPK1KDRPLK4CHEK1 | |
| SCHEMBL6977133 | 0.78 | MAPT (0.57) | IGF1RMAPK1KDRPLK4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |