Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.70 |
| ▸ | MEF2D | Q14814 | 9/20 | 0.70 |
| ▸ | EP300 | Q09472 | 4/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1066694 | 1.00 | HDAC1 (0.78) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL1066692 | 1.00 | HDAC1 (0.78) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL8348022 | 0.88 | HDAC1 (0.80) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL1079270 | 0.88 | HDAC1 (0.80) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL1079272 | 0.88 | HDAC1 (0.80) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL1064142 | 0.88 | HDAC1 (0.72) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL1064141 | 0.88 | HDAC1 (0.72) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL1065917 | 0.88 | HDAC1 (1.00) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL8348764 | 0.88 | HDAC1 (1.00) | HDAC1HDAC4MEF2DEP300 | |
| SCHEMBL1065916 | 0.88 | HDAC1 (1.00) | HDAC1HDAC4MEF2DEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| EP-1590340-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2010-04-07 | — | — | EP | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |