Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.70 |
| ▸ | PDE4A | P27815 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203750 | 1.00 | PDE4B (0.70) | PDE4BPDE4APDE4DPTGER4CYP3A4 | |
| SCHEMBL6064036 | 0.92 | PDE4B (0.59) | PDE4BPDE4APDE4DPTGER4CYP3A4 | |
| SCHEMBL6063525 | 0.91 | PDE4B (0.58) | PDE4BPDE4APDE4DPTGER4 | |
| SCHEMBL8295429 | 0.90 | PDE4B (0.58) | PDE4BPDE4APDE4DPTGER4CYP3A4 | |
| SCHEMBL8353996 | 0.87 | PDE4B (0.53) | PDE4BPDE4APDE4DPTGER4CYP3A4 | |
| SCHEMBL6063303 | 0.87 | PDE4B (0.53) | PDE4BPDE4APDE4DPTGER4CYP3A4 | |
| SCHEMBL8353362 | 0.85 | PDE4B (0.73) | PDE4BPDE4APDE4DPTGER4 | |
| SCHEMBL5207605 | 0.85 | PDE4B (0.73) | PDE4BPDE4APDE4DPTGER4 | |
| SCHEMBL8351201 | 0.85 | PDE4B (0.73) | PDE4BPDE4APDE4DPTGER4 | |
| SCHEMBL8351888 | 0.85 | PDE4B (0.70) | PDE4BPDE4APDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003068235-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |