Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.80 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.54 |
| ▸ | SCD | O00767 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064695 | 0.90 | HDAC1 (0.79) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL13390113 | 0.90 | HDAC1 (0.79) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL1065031 | 0.89 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL1066153 | 0.87 | HDAC1 (0.78) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL1063811 | 0.84 | HDAC1 (0.73) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL1064329 | 0.83 | HDAC1 (0.80) | HDAC1 | |
| SCHEMBL13390323 | 0.82 | HDAC1 (0.69) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL1060520 | 0.82 | HDAC1 (0.80) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL23498234 | 0.81 | SCD (0.59) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL1060648 | 0.80 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |