Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TET3 | O43151 | 2/20 | 0.48 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.48 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.48 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.48 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972474 | 0.88 | TSHR (0.65) | TSHRALOX15ATMKMT2ATET3 | |
| SCHEMBL7466581 | 0.88 | TSHR (0.53) | TSHRALOX15ATMKMT2ATET3 | |
| SCHEMBL6543780 | 0.83 | TSHR (0.63) | TSHRALOX15ATMKMT2ATET3 | |
| SCHEMBL21408986 | 0.81 | TSHR (0.60) | TSHRALOX15ATMKMT2ATET3 | |
| SCHEMBL19183400 | 0.81 | TSHR (0.60) | TSHRALOX15ATMKMT2ATET3 | |
| SCHEMBL27381366 | 0.80 | KMT2A (0.65) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL13543984 | 0.80 | TSHR (0.64) | TSHRALOX15ATMKMT2ATET3 | |
| SCHEMBL10253634 | 0.79 | TSHR (0.58) | TSHRALOX15ATMOPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL8635061 | 0.79 | KMT2A (0.63) | KMT2ATET3FBXL19CXXC5TET1 | |
| Hydrochloric Acid SCHEMBL8355556 | 0.78 | KMT2A (0.47) | KMT2ATET3FBXL19CXXC5TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |
| US-5661160-A | ADMINISTERING AN ANTITUSSIVE AGENT FOR TREATING COUGH; TACHYKININ ANTAGONISM, SUBSTANCE P AND NEUROKININ A ANTAGONISM | MERRELL PHARMACEUTICALS INC. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5648366-A | TACHYKININ ANTAGONISTS USEFUL IN TREATING ASTHMA | MERRELL PHARMACEUTICALS INC. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5635510-A | TACHYKININ (ESPECIALLY SUBSTANCE P AND NEUROKININ A) ANTAGONISTS; ANTIINFLAMMATORY AGENTS, ANALGESICS; NERVOUS SYSTEM DISORDERS; BRONCHODILATOR AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-06-03 | — | — | US | disclosed |