Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | AHR | P35869 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22926426 | 0.86 | TAAR1 (0.80) | KDM4ETAAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL4276324 | 0.86 | TAAR1 (0.64) | KDM4ETAAR1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL1446121 | 0.83 | TAAR1 (0.54) | KDM4ETAAR1ALDH1A1AHRCYP1A2 | |
| SCHEMBL29555874 | 0.82 | MAPT (0.66) | KDM4ETAAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL1446022 | 0.82 | TAAR1 (0.53) | KDM4ETAAR1ALDH1A1AHRCYP1A2 | |
| SCHEMBL1446421 | 0.81 | TAAR1 (0.54) | KDM4ETAAR1ALDH1A1AHRCYP1A2 | |
| SCHEMBL1447166 | 0.81 | TAAR1 (0.54) | KDM4ETAAR1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL1068667 | 0.81 | CYP1A2 (0.53) | KDM4ETAAR1ALDH1A1HPGDAHR | |
| SCHEMBL22926673 | 0.79 | TAAR1 (1.00) | KDM4ETAAR1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL1446136 | 0.79 | TAAR1 (0.52) | KDM4ETAAR1ALDH1A1AHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |
| WO-2004064730-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2004-08-05 | — | — | WO | disclosed |