SCHEMBL8352293

SCHEMBL8352293

COc1cc(CNCc2ccc(/C=C/C(=O)Nc3ccccc3[N+](=O)[O-])cc2)cc(C)c1OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 10/20 0.54
RAB9A P51151 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
NPC1 O15118 1/20 0.51
MAPT P10636 6/20 0.50
HDAC3 O15379 4/20 0.49
HDAC2 Q92769 4/20 0.49
HDAC8 Q9BY41 4/20 0.49
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
CYP2C19 P33261 1/20 0.48
TRPV1 Q8NER1 1/20 0.48
ALDH1A1 P00352 3/20 0.47
LMNA P02545 1/20 0.47
POLB P06746 1/20 0.47
ATM Q13315 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2734354 0.95 HDAC1 (0.59) HDAC1RAB9ASMN1; SMN2NPC1MAPT
SCHEMBL1062902 0.95 HDAC1 (0.59) HDAC1RAB9ASMN1; SMN2NPC1MAPT
SCHEMBL1062904 0.95 HDAC1 (0.59) HDAC1RAB9ASMN1; SMN2NPC1MAPT
SCHEMBL3630366 0.85 HDAC1 (0.51) HDAC1RAB9ASMN1; SMN2NPC1MAPT
SCHEMBL1060486 0.82 HDAC1 (0.60) HDAC1RAB9ASMN1; SMN2NPC1MAPT
SCHEMBL1060488 0.82 HDAC1 (0.60) HDAC1RAB9ASMN1; SMN2NPC1MAPT
SCHEMBL3630368 0.81 HDAC1 (0.54) HDAC1RAB9ASMN1; SMN2NPC1MAPT
SCHEMBL2732582 0.80 HDAC1 (0.80) HDAC1HDAC3HDAC2HDAC8HDAC4
SCHEMBL1065134 0.80 HDAC1 (0.80) HDAC1HDAC3HDAC2HDAC8HDAC4
SCHEMBL1065131 0.80 HDAC1 (0.80) HDAC1HDAC3HDAC2HDAC8HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003024448-A2 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2003-03-27 WO disclosed