Oxalic Acid

Oxalic Acid

SCHEMBL8353249

CC(=O)O.CC(C)C1c2ccc(F)cc2CCC1(O)CCN(C)CCCc1nc2ccccc2[nH]1.O=C(O)C(=O)O.O=C(O)C(=O)O

nearest known ligand 0.90

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1SLC6A4

The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 1/20 0.69
OPRM1 known ✓ P35372 1/20 0.69
CYP3A4 P08684 5/20 0.90
CACNA1H O95180 12/20 0.72
CACNA1C Q13936 10/20 0.72
CYP2D6 P10635 4/20 0.72
MAPT P10636 4/20 0.70
CACNA1B Q00975 3/20 0.70
MEN1 O00255 3/20 0.70
KMT2A Q03164 3/20 0.70
ALDH1A1 P00352 2/20 0.70
KCNH2 Q12809 2/20 0.69
ABCB11 O95342 2/20 0.69
NPC1 O15118 2/20 0.69
TP53 P04637 2/20 0.69
CYP1A2 P05177 2/20 0.69
ALOX15 P16050 2/20 0.69
MAPK1 P28482 2/20 0.69
CYP2C19 P33261 2/20 0.69
THPO P40225 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7267019 0.95 CYP3A4 (1.00) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
SCHEMBL7449450 0.95 CYP3A4 (1.00) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
SCHEMBL22761579 0.95 CYP3A4 (1.00) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
SCHEMBL7273270 0.93 CYP3A4 (0.95) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
SCHEMBL7266333 0.92 CYP3A4 (0.94) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
SCHEMBL7267079 0.92 CYP3A4 (0.94) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
SCHEMBL7266465 0.92 CYP3A4 (0.94) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
Hydrochloric Acid SCHEMBL10539326 0.91 CYP3A4 (0.92) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
Hydrochloric Acid SCHEMBL7266400 0.91 CYP3A4 (0.92) CYP3A4CACNA1HCACNA1CCYP2D6MAPT
SCHEMBL8359519 0.87 CYP3A4 (0.79) CYP3A4CACNA1HCACNA1CCYP2D6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5892055-A Preparation of mibefradil via an acetamide anion ROCHE COLORADO CORPORATION (US) 1999-04-06 US disclosed
US-5808088-A Preparation of mibefradil via an acetamide anion ROCHE COLORADO CORPORATION (US) 1998-09-15 US disclosed