Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL833841 | 1.00 | KDR (0.44) | KDRPDGFRBMAPTSLC16A3GRM5 | |
| SCHEMBL836874 | 0.91 | KDR (0.49) | KDRPDGFRBMAPT | |
| SCHEMBL836873 | 0.91 | KDR (0.49) | KDRPDGFRBMAPT | |
| SCHEMBL836650 | 0.85 | KDR (0.53) | KDRPDGFRBMAPTSLC16A3 | |
| SCHEMBL835062 | 0.85 | KDR (0.53) | KDRPDGFRBMAPTSLC16A3 | |
| SCHEMBL836858 | 0.85 | KDR (0.53) | KDRPDGFRBMAPTSLC16A3 | |
| SCHEMBL834289 | 0.84 | KDR (0.41) | KDRPDGFRBMAPTSLC16A3 | |
| SCHEMBL834288 | 0.84 | KDR (0.41) | KDRPDGFRBMAPTSLC16A3 | |
| SCHEMBL835084 | 0.84 | KDR (0.48) | KDRPDGFRBMAPTSLC16A3 | |
| SCHEMBL835627 | 0.84 | KDR (0.48) | KDRPDGFRBMAPTSLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143410-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110263611-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2011-10-27 | — | — | US | disclosed |
| US-7915443-B2 | Sulfoximines as kinase inhibitors | ALLERGAN, INC. (US) | 2011-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263611-A1 | Kinase Inhibitors | PTK2, MAP3K6, MAP3K20 | KDR 51/4885PDGFRB 368/4885MAPT 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.