Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.53 |
| ▸ | CCND1 | P24385 | 9/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.46 |
| ▸ | PRKCG | P05129 | 4/20 | 0.46 |
| ▸ | PRKCB | P05771 | 4/20 | 0.46 |
| ▸ | PRKCA | P17252 | 4/20 | 0.46 |
| ▸ | PRKCH | P24723 | 4/20 | 0.46 |
| ▸ | PRKCI | P41743 | 4/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8355122 | 1.00 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8353958 | 0.93 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14440404 | 0.93 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14440428 | 0.91 | PRKCQ (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8352935 | 0.91 | PRKCQ (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8351539 | 0.91 | PRKCQ (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8354981 | 0.85 | CDK4 (0.55) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14440333 | 0.84 | CDK4 (0.55) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14440360 | 0.84 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL14440359 | 0.84 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051887-A1 | N-CARBACYCLE MONOSUBSTITUTED INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS | NAD AG (DE) | 2003-06-26 | — | — | WO | disclosed |