SCHEMBL8355155

SCHEMBL8355155

NC(=O)C1CCCN(c2ccc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cn3)cn2)C1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 18/20 0.64
KCNH2 Q12809 3/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4858074 0.90 F10 (0.63) F10KCNH2
SCHEMBL4858972 0.87 F10 (0.69) F10KCNH2
SCHEMBL4848739 0.86 F10 (0.67) F10KCNH2
SCHEMBL4855425 0.86 F10 (0.68) F10KCNH2
SCHEMBL4859930 0.85 F10 (0.57) F10KCNH2
Hydrochloric Acid SCHEMBL7075564 0.82 F10 (0.58) F10KCNH2
SCHEMBL5207826 0.81 F10 (0.72) F10KCNH2
SCHEMBL14394521 0.81 F10 (0.81) F10KCNH2
SCHEMBL4854178 0.81 F10 (0.53) F10KCNH2
SCHEMBL4848558 0.81 F10 (0.74) F10KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7449457-B2 Substituted heterocyclic carboxamides with antithrombotic activity ELI LILLY AND COMPANY (US) 2008-11-11 US disclosed
US-7449457-B2 Substituted heterocyclic carboxamides with antithrombotic activity ELI LILLY AND COMPANY (US) 2008-11-11 US disclosed
WO-2003050088-A1 SUBSTITUTED HETEROCYCLIC CARBOXAMIDES WITH ANTITHROMBOTIC ACTIVITY ELI LILLY AND COMPANY (US) 2003-06-19 WO disclosed