Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 10/20 | 0.76 |
| ▸ | MAOA | P21397 | 4/20 | 0.76 |
| ▸ | ABL1 | P00519 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8355128 | 0.87 | KDM1A (0.87) | KDM1AMAOANPSR1MEN1KMT2A | |
| SCHEMBL8356809 | 0.86 | KDM1A (1.00) | KDM1AMAOANPSR1MEN1KMT2A | |
| SCHEMBL3453105 | 0.84 | ABL1 (0.63) | KDM1AMAOAABL1NPSR1 | |
| SCHEMBL8356804 | 0.82 | KDM1A (0.67) | KDM1AMAOANPSR1MEN1KMT2A | |
| SCHEMBL8355657 | 0.81 | KDM1A (0.77) | KDM1AMAOANPSR1MEN1KMT2A | |
| SCHEMBL8360649 | 0.81 | KDM1A (0.66) | KDM1AMAOANPSR1MEN1KMT2A | |
| SCHEMBL8355143 | 0.81 | MEN1 (0.84) | KDM1AMAOANPSR1MEN1KMT2A | |
| SCHEMBL8356715 | 0.81 | MEN1 (0.66) | KDM1AMAOANPSR1MEN1KMT2A | |
| SCHEMBL8360679 | 0.80 | MEN1 (0.74) | KDM1AMAOANPSR1MEN1KMT2A | |
| SCHEMBL8356869 | 0.80 | MEN1 (0.74) | KDM1AMAOANPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | claimed |
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0819681-A2 | N-(4-Aryl-thiazol-2-yl)-sulfonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-21 | — | — | EP | disclosed |