SCHEMBL8355491

SCHEMBL8355491

COC(=O)[C@H]1CC[C@H]1C(=O)OC

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.52
CHRM4 P08173 1/20 0.52
CHRM3 P20309 1/20 0.52
CHRNB2 P17787 2/20 0.44
CHRNA4 P43681 2/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44
CHRNA7 P36544 1/20 0.44
CYP3A4 P08684 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42
HSD17B10 Q99714 1/20 0.42
PPM1B O75688 1/20 0.41
PTPN1 P18031 1/20 0.41
PPP1CC P36873 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2742462 1.00 CHRM2 (0.52) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL8226507 1.00 CHRM2 (0.52) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL2965074 1.00 CHRM2 (0.52) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL31285391 0.90 CHRM2 (0.48) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL974796 0.90 CHRM2 (0.48) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL974400 0.90 CHRM2 (0.48) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL8494369 0.90 CHRM2 (0.48) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL974399 0.90 CHRM2 (0.48) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL1298159 0.90 CHRM2 (0.48) CHRM2CHRM4CHRM3CHRNB2CHRNA4
SCHEMBL12921430 0.90 CHRM2 (0.48) CHRM2CHRM4CHRM3CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7598242-B2 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION (US) 2009-10-06 US disclosed
US-7598242-B2 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION (US) 2009-10-06 US disclosed
WO-2003053915-A2 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS SCHERING CORPORATION (US) 2003-07-03 WO disclosed