Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | SLC28A3 | Q9HAS3 | 2/20 | 0.36 |
| ▸ | SYNJ2 | O15056 | 2/20 | 0.36 |
| ▸ | IGF2R | P11717 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL190256 | 0.95 | CDK1 (0.56) | CDK1CCNB1CA2CA9MEN1 | |
| SCHEMBL925520 | 0.95 | CDK1 (0.63) | CDK1CCNB1CA2CA9MEN1 | |
| Sulfuric Acid SCHEMBL6376476 | 0.91 | CDK1 (0.57) | CDK1CCNB1CA2CA9MEN1 | |
| Nitric Acid SCHEMBL6009046 | 0.89 | CDK1 (0.55) | CDK1CCNB1CA2CA9MEN1 | |
| SCHEMBL2471895 | 0.87 | CDK1 (0.60) | CDK1CCNB1CA2CA9MEN1 | |
| SCHEMBL18167470 | 0.85 | CDK1 (0.58) | CDK1CCNB1CA2CA9MEN1 | |
| SCHEMBL875991 | 0.84 | CDK1 (0.66) | CDK1CCNB1CA2CA9MEN1 | |
| SCHEMBL8619982 | 0.84 | CDK1 (0.57) | CDK1CCNB1CA2CA9MEN1 | |
| Sucrose SCHEMBL10389500 | 0.83 | CDK1 (0.73) | CDK1CCNB1CA2CA9MEN1 | |
| SCHEMBL8206204 | 0.83 | CDK1 (0.56) | CDK1CCNB1CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999030688-A1 | METHODS OF LYOPHILIZING SOLUTIONS | AUFFRET ANTHONY (GB) | 1999-06-24 | — | — | WO | disclosed |