Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 3/20 | 0.56 |
| ▸ | TACR1 | P25103 | 3/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | TACR3 | P29371 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8640231 | 0.99 | TACR2 (0.55) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL1421506 | 0.90 | TACR2 (0.66) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL8310101 | 0.90 | TACR2 (0.66) | TACR2TACR1HRH1TACR3 | |
| Hydrochloric Acid SCHEMBL19209904 | 0.89 | TACR2 (0.65) | TACR2TACR1HRH1TACR3 | |
| Hydrochloric Acid SCHEMBL8304865 | 0.89 | TACR2 (0.65) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL8352862 | 0.89 | TACR2 (0.56) | TACR2TACR1HRH1TACR3 | |
| Hydrochloric Acid SCHEMBL8636337 | 0.88 | TACR2 (0.56) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL8349902 | 0.88 | TACR2 (0.58) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL8641307 | 0.88 | TACR2 (0.61) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL8355660 | 0.88 | TACR2 (0.56) | TACR2TACR1HRH1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | claimed |
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |
| EP-0696280-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMA (US) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994026735-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-24 | — | — | WO | disclosed |