Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1,2-Dichlorobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | CES2 | O00748 | 3/20 | 0.57 |
| ▸ | CES1 | P23141 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2-Dichlorobenzene SCHEMBL27871244 | 1.00 | TSHR (0.67) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27754908 | 0.88 | TSHR (0.59) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL8528441 | 0.88 | TSHR (0.59) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27273002 | 0.87 | TSHR (0.67) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL11850148 | 0.86 | TSHR (0.91) | TSHRLMNAALDH1A1CES2CES1 | |
| Bicarbonate SCHEMBL11009844 | 0.85 | CYP2A6 (0.59) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL29087567 | 0.85 | TSHR (0.56) | TSHRLMNAALDH1A1CES2CES1 | |
| Bicarbonate SCHEMBL4865957 | 0.85 | CYP2A6 (0.59) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL28110944 | 0.85 | TSHR (0.56) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27435182 | 0.85 | TSHR (0.56) | TSHRLMNAALDH1A1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102660111-B | Polycarbonate optical waveguide material and preparation method thereof | UNIV SOUTHEAST | 2013-09-04 | — | — | CN | claimed |
| CN-102660111-A | Polycarbonate optical waveguide material and preparation method thereof | UNIV SOUTHEAST | 2012-09-12 | — | — | CN | claimed |
| CN-102660111-B | Polycarbonate optical waveguide material and preparation method thereof | UNIV SOUTHEAST | 2013-09-04 | — | — | CN | disclosed |
| CN-102660111-A | Polycarbonate optical waveguide material and preparation method thereof | UNIV SOUTHEAST | 2012-09-12 | — | — | CN | disclosed |
| WO-1999041756-A1 | INTRINSICALLY CONDUCTIVE POLYMER BLENDS HAVING A LOW PERCOLATION THRESHOLD | ZIPPERLING KESSLER & CO. (GMBH & CO.) (DE) | 1999-08-19 | — | — | WO | disclosed |