Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 16/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.61 |
| ▸ | P2RY12 | Q9H244 | 13/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PTAFR | P25105 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PDE1A | P54750 | 1/20 | 0.60 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350200 | 0.88 | PDE3B (0.61) | PDE3BPDE3AP2RY12KDM4EMEN1 | |
| SCHEMBL5630679 | 0.85 | PDE3B (0.60) | PDE3BPDE3AP2RY12KDM4EMEN1 | |
| SCHEMBL17874412 | 0.85 | PDE3B (0.60) | PDE3BPDE3AP2RY12KDM4EMEN1 | |
| SCHEMBL8354652 | 0.83 | PDE3B (0.52) | PDE3BPDE3AP2RY12KDM4EMEN1 | |
| SCHEMBL9036354 | 0.82 | PDE3B (0.58) | PDE3BPDE3AP2RY12KDM4EMEN1 | |
| SCHEMBL11276302 | 0.81 | PDE3B (0.56) | PDE3BPDE3AP2RY12KDM4EMEN1 | |
| SCHEMBL5474312 | 0.81 | PDE3B (0.55) | PDE3BPDE3AP2RY12KDM4EMEN1 | |
| SCHEMBL7802210 | 0.80 | KDM4E (0.52) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL16409780 | 0.80 | HDAC1 (0.70) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL7802190 | 0.80 | PDE3B (0.51) | PDE3BPDE3AP2RY12KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066619-A1 | Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity | ARTESIAN THERAPEUTICS, INC. (US) | 2007-03-22 | — | — | US | disclosed |
| US-20070066619-A1 | Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity | ARTESIAN THERAPEUTICS, INC. (US) | 2007-03-22 | — | — | US | disclosed |
| WO-2004033444-A1 | DIHYDROPYRIDINE COMPOUNDS HAVING SIMULTANEOUS ABILITY TO BLOCK L-TYPE CALCIUM CHANNELS AND TO INHIBIT PHOSPHODIESTERASE TYPE 3 ACTIVITY | ARTESIAN THERAPEUTICS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066619-A1 | Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity | CACNA1C, PDE3A, PDE3B | PDE3B 3/4885PDE3A 2/4885P2RY12 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.