Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 15/20 | 1.00 |
| ▸ | PSEN2 | P49810 | 15/20 | 1.00 |
| ▸ | APH1B | Q8WW43 | 15/20 | 1.00 |
| ▸ | NCSTN | Q92542 | 15/20 | 1.00 |
| ▸ | APH1A | Q96BI3 | 15/20 | 1.00 |
| ▸ | PSENEN | Q9NZ42 | 15/20 | 1.00 |
| ▸ | APP | P05067 | 6/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358695 | 0.94 | PSEN1 (0.88) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8358697 | 0.93 | PSEN1 (0.86) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8358712 | 0.91 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8354702 | 0.90 | PSEN1 (0.88) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359153 | 0.89 | PSEN1 (0.89) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8358115 | 0.88 | PSEN1 (0.87) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359164 | 0.88 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8355014 | 0.87 | PSEN1 (0.81) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8358717 | 0.87 | PSEN1 (0.77) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359138 | 0.87 | PSEN1 (0.77) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003014075-A2 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |