Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 7/20 | 0.97 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474303 | 0.98 | MPL (1.00) | MPLLTA4HKDM1ATYRALDH1A1 | |
| SCHEMBL474311 | 0.86 | MPL (1.00) | MPLLTA4HTYRALDH1A1RAB9A | |
| SCHEMBL1803094 | 0.82 | MPL (0.71) | MPLLTA4HKDM1ATYRALDH1A1 | |
| SCHEMBL1801513 | 0.80 | MPL (0.68) | MPLLTA4HTYRALDH1A1RAB9A | |
| SCHEMBL31052408 | 0.80 | MPL (0.73) | MPLLTA4HTYRALDH1A1RAB9A | |
| SCHEMBL8117023 | 0.79 | MPL (0.67) | MPLKDM1AALDH1A1RAB9ANPC1 | |
| SCHEMBL31006087 | 0.79 | MPL (0.67) | MPLTYRALDH1A1RAB9AALOX5 | |
| SCHEMBL1916792 | 0.79 | MPL (0.67) | MPLTYRALDH1A1RAB9AALOX5 | |
| SCHEMBL1198648 | 0.78 | MPL (0.66) | MPLLTA4HKDM1AALDH1A1RAB9A | |
| SCHEMBL1198429 | 0.78 | MPL (0.66) | MPLLTA4HKDM1AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | disclosed |