Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12820668 | 0.83 | CYP11B1 (0.58) | CYP19A1ALDH1A1GALR3RAB9ATSHR | |
| SCHEMBL8441652 | 0.81 | CYP19A1 (0.49) | CYP19A1ALDH1A1GALR3RAB9ATSHR | |
| SCHEMBL9267101 | 0.77 | CYP11B1 (0.58) | ALDH1A1TSHRCYP11B1CYP11B2GAA | |
| SCHEMBL7478451 | 0.77 | CYP11B1 (0.69) | CYP19A1CYP11B1CYP11B2FNTAFNTB | |
| Hydrochloric Acid SCHEMBL7802265 | 0.76 | CYP11B1 (0.67) | CYP19A1CYP11B1CYP11B2FNTAFNTB | |
| Hydrochloric Acid SCHEMBL7473105 | 0.76 | CYP11B1 (0.67) | CYP19A1CYP11B1CYP11B2FNTAFNTB | |
| Hydrochloric Acid SCHEMBL7847528 | 0.76 | CYP19A1 (0.52) | CYP19A1ALDH1A1GALR3RAB9ATSHR | |
| SCHEMBL27855265 | 0.75 | CYP11B1 (0.48) | CYP19A1ALDH1A1GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL1064583 | 0.74 | SIRT2 (0.45) | CYP19A1ALDH1A1GALR3RAB9ATSHR | |
| SCHEMBL1950222 | 0.72 | CYP11B1 (0.63) | CYP19A1ALDH1A1GALR3RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874452-A | Biheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5859035-A | Arylheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5854265-A | Biheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1998-12-29 | — | — | US | disclosed |