Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8343973 | 0.85 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6604913 | 0.81 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| Bromide SCHEMBL4031335 | 0.77 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6180752 | 0.76 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4025781 | 0.76 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4027089 | 0.76 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4037954 | 0.76 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5257490 | 0.76 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7448426 | 0.75 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6184825 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003105815-A1 | COMBINATION OF PDE-V INHIBITORS AND NK1 ANTAGONISTS FOR THE TREATMENT OF DEPRESSION | PFIZER PRODUCTS INC. (US) | 2003-12-24 | — | — | WO | disclosed |