Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 14/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.68 |
| ▸ | NCOR2 | Q9Y618 | 6/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254962 | 1.00 | HDAC2 (0.68) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL4831736 | 0.90 | HDAC3 (0.56) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL14254961 | 0.86 | HDAC3 (0.52) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL4831730 | 0.86 | HPGD (0.52) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL13288509 | 0.85 | HDAC2 (0.61) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL4828503 | 0.82 | HPGD (0.48) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL8271583 | 0.82 | HDAC2 (0.68) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL13288542 | 0.81 | HDAC2 (0.60) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL14254985 | 0.80 | HDAC1 (0.71) | HDAC2HDAC1HDAC11HDAC6HDAC8 | |
| SCHEMBL8337680 | 0.80 | HDAC1 (0.71) | HDAC2HDAC1HDAC11HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1443928-B1 | TREATMENT OF NEURODEGENERATIVE DISEASES AND CANCER OF THE BRAIN | SLOAN KETTERING INST CANCER (US) | 2011-07-27 | — | — | EP | disclosed |
| EP-2269609-A2 | Treatment of neurodegenerative diseases and cancer of the brain with SAHA | Sloan-Kettering Institute for Cancer Research (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2003032921-A2 | TREATMENT OF NEURODEGENERATIVE DISEASES AND CANCER OF THE BRAIN | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2003-04-24 | — | — | WO | disclosed |