Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 9/20 | 0.36 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | PDE6A | P16499 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F3 | P13726 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363686 | 0.91 | F7 (0.37) | F7JAK2JAK1JAK3PDE5A | |
| SCHEMBL8363478 | 0.90 | F7 (0.39) | F7PHLPP2PDE5APDE6AF2 | |
| SCHEMBL8363216 | 0.90 | F7 (0.38) | F7JAK2JAK1JAK3PDE5A | |
| SCHEMBL6798274 | 0.86 | F7 (0.40) | F7JAK2JAK1JAK3F2 | |
| SCHEMBL6790420 | 0.81 | F7 (0.60) | F7F2F3 | |
| SCHEMBL8360899 | 0.80 | F7 (0.40) | F7PDE5APDE6AF2F3 | |
| SCHEMBL8360913 | 0.79 | F7 (0.42) | F7PDE5APDE6AF2F3 | |
| SCHEMBL8360908 | 0.77 | F7 (0.53) | F7PHLPP2F2F3 | |
| SCHEMBL8363709 | 0.76 | F7 (0.51) | F7F2F3 | |
| SCHEMBL8362044 | 0.76 | F7 (0.47) | F7F2F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028729-A2 | PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |