SCHEMBL8360922

SCHEMBL8360922

Cc1ccc(Cl)c(-c2cccnc2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.51
MAOA P21397 1/20 0.50
MAOB P27338 1/20 0.50
MAP2K4 P45985 1/20 0.49
CYP3A4 P08684 5/20 0.49
CYP2D6 P10635 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2C19 P33261 2/20 0.47
CYP2E1 P05181 1/20 0.47
CYP2B6 P20813 1/20 0.47
NPC1 O15118 4/20 0.47
RAB9A P51151 4/20 0.47
ALDH1A1 P00352 2/20 0.47
CYP1A2 P05177 2/20 0.47
TP53 P04637 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
MAPT P10636 1/20 0.47
KDM4E B2RXH2 1/20 0.47
HPGD P15428 1/20 0.47
HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25871383 0.84 CYP2A6 (0.56) CYP2A6MAOAMAOBMAP2K4CYP3A4
SCHEMBL3424504 0.84 CYP2A6 (0.56) CYP2A6MAOAMAOBMAP2K4CYP3A4
SCHEMBL14003400 0.82 CYP2A6 (0.54) CYP2A6MAOAMAOBMAP2K4CYP3A4
SCHEMBL7582709 0.82 CYP2A6 (0.53) CYP2A6CYP3A4CYP2C19NPC1RAB9A
SCHEMBL4452255 0.81 CYP2A6 (0.53) CYP2A6MAOAMAOBMAP2K4CYP3A4
SCHEMBL2665898 0.79 CYP2A6 (0.51) CYP2A6MAOAMAOBMAP2K4CYP3A4
SCHEMBL2652392 0.79 CYP11B1 (0.54) CYP2A6CYP3A4NPC1RAB9AALDH1A1
SCHEMBL2652567 0.79 AXL (0.56) CYP2A6CYP3A4NPC1RAB9AALDH1A1
SCHEMBL6171120 0.79 CYP2A6 (0.51) CYP2A6MAOAMAOBMAP2K4CYP3A4
SCHEMBL14493330 0.79 CYP2A6 (0.54) CYP2A6MAOAMAOBMAP2K4CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002074773-A1 IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS MERCK SHARP & DOHME LIMITED (GB) 2002-09-26 WO disclosed