Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.70 |
| ▸ | PDE6D | O43924 | 1/20 | 0.69 |
| ▸ | PDE6A | P16499 | 1/20 | 0.69 |
| ▸ | PDE6G | P18545 | 1/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.69 |
| ▸ | PDE6B | P35913 | 1/20 | 0.69 |
| ▸ | PDE6C | P51160 | 1/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.69 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.69 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16298479 | 0.92 | PDE5A (0.72) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8362679 | 0.91 | PDE5A (0.83) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8362023 | 0.85 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8362719 | 0.84 | PDE5A (0.80) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8362524 | 0.84 | PDE5A (0.82) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8358715 | 0.82 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8361585 | 0.81 | PDE5A (0.77) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8360720 | 0.81 | PDE5A (0.74) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8360098 | 0.81 | PDE5A (0.87) | PDE5APDE6DPDE6APDE6GPDE4A | |
| SCHEMBL8360702 | 0.80 | PDE5A (0.72) | PDE5APDE6DPDE6APDE6GPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003042216-A1 | POLYCYCLIC GUANINE DERIVATIVE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORPORATION (US) | 2003-05-22 | — | — | WO | disclosed |