Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361734 | 0.99 | PDE5A (0.56) | PDE5ADPP4 | |
| SCHEMBL8210189 | 0.96 | PDE5A (0.56) | PDE5A | |
| SCHEMBL8216613 | 0.95 | PDE5A (0.57) | PDE5A | |
| SCHEMBL6626317 | 0.95 | PDE5A (0.52) | PDE5ADPP4 | |
| SCHEMBL6628887 | 0.91 | PDE5A (0.55) | PDE5ADPP4 | |
| SCHEMBL6681700 | 0.90 | PDE5A (0.51) | PDE5A | |
| SCHEMBL8363356 | 0.90 | PDE5A (0.51) | PDE5A | |
| SCHEMBL10201566 | 0.87 | PDE5A (0.49) | PDE5A | |
| SCHEMBL7886157 | 0.87 | PDE5A (0.51) | PDE5ADPP4 | |
| SCHEMBL10201556 | 0.87 | PDE5A (0.45) | PDE5ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421084-B1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORP (US) | 2008-05-14 | — | — | EP | disclosed |
| EP-1790652-A1 | Polycyclic guanine phosphodiesterase V inhibitors | Schering Corporation (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2003020724-A1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |