Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363849 | 0.85 | KCNA5 (0.61) | KMT2AMEN1ALDH1A1PSEN1PSEN2 | |
| SCHEMBL20387947 | 0.79 | KMT2A (0.67) | KMT2AMEN1USP2ALDH1A1HDAC3 | |
| SCHEMBL20839243 | 0.79 | HDAC8 (0.65) | KMT2AMEN1USP2ALDH1A1HDAC3 | |
| SCHEMBL20393932 | 0.78 | KMT2A (0.69) | KMT2AMEN1USP2ALDH1A1HDAC3 | |
| SCHEMBL20847632 | 0.77 | HDAC8 (0.74) | KMT2AMEN1USP2ALDH1A1HDAC3 | |
| SCHEMBL20382088 | 0.75 | PDE6D (0.55) | KMT2AMEN1PSEN1PSEN2APH1B | |
| SCHEMBL1682268 | 0.74 | USP2 (0.55) | KMT2AMEN1USP2ALDH1A1HDAC3 | |
| SCHEMBL1574683 | 0.74 | CNR1 (0.58) | KMT2AMEN1USP2ALDH1A1HDAC3 | |
| SCHEMBL2958329 | 0.73 | CNR2 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14842380 | 0.73 | MEN1 (1.00) | KMT2AMEN1USP2ALDH1A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013527-A1 | SULFONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |