Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.74 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363336 | 0.97 | EGFR (0.75) | EGFRERBB2CHEK2ROS1FLT3 | |
| SCHEMBL8367286 | 0.95 | EGFR (0.71) | EGFRERBB2CHEK2ROS1FLT3 | |
| SCHEMBL8367607 | 0.93 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL8364155 | 0.91 | EGFR (0.83) | EGFRERBB2 | |
| SCHEMBL8368189 | 0.90 | EGFR (0.87) | EGFRERBB2CHEK2ROS1FLT3 | |
| SCHEMBL8367097 | 0.90 | EGFR (0.76) | EGFRERBB2CHEK2ROS1FLT3 | |
| SCHEMBL8361665 | 0.90 | EGFR (0.87) | EGFRERBB2CHEK2ROS1FLT3 | |
| SCHEMBL8361544 | 0.90 | EGFR (0.74) | EGFRERBB2CHEK2ROS1FLT3 | |
| SCHEMBL8367614 | 0.88 | EGFR (0.79) | EGFRERBB2CHEK2ROS1FLT3 | |
| SCHEMBL8367271 | 0.88 | EGFR (0.82) | EGFRERBB2CHEK2ROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |