Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | ROS1 | P08922 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 7/20 | 0.55 |
| ▸ | ILK | Q13418 | 1/20 | 0.47 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.47 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361805 | 0.96 | AURKB (0.61) | EGFRAURKBERBB2CHEK2ROS1 | |
| SCHEMBL8367372 | 0.95 | AURKB (0.58) | EGFRAURKBERBB2CHEK2ROS1 | |
| SCHEMBL8367193 | 0.93 | EGFR (0.61) | EGFRAURKBERBB2CHEK2ROS1 | |
| SCHEMBL8367797 | 0.90 | EGFR (0.57) | EGFRAURKBERBB2CHEK2ROS1 | |
| SCHEMBL8365875 | 0.89 | ERBB2 (0.60) | EGFRAURKBERBB2CHEK2ROS1 | |
| SCHEMBL8365488 | 0.89 | EGFR (0.56) | EGFRAURKBERBB2CHEK2ROS1 | |
| SCHEMBL8364328 | 0.88 | EGFR (0.59) | EGFRAURKBERBB2CHEK2ROS1 | |
| SCHEMBL8367261 | 0.88 | EGFR (0.55) | EGFRAURKBERBB2CHEK2ROS1 | |
| SCHEMBL8364953 | 0.87 | AURKA (0.55) | EGFRAURKBERBB2AURKAILK | |
| SCHEMBL8365886 | 0.87 | EGFR (0.59) | EGFRAURKBERBB2ERBB4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |