SCHEMBL8364475

SCHEMBL8364475

CCOC(=O)C=C(C#N)c1ccc(OC)c(OC)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 6/20 0.54
ALDH1A1 P00352 5/20 0.52
PKM P14618 1/20 0.52
HTT P42858 1/20 0.52
PDE4A P27815 5/20 0.49
PDE4C Q08493 5/20 0.49
PDE4D Q08499 5/20 0.49
MAPT P10636 3/20 0.48
KDM4E B2RXH2 2/20 0.48
CYP2C19 P33261 2/20 0.48
POLB P06746 1/20 0.48
ELANE P08246 1/20 0.48
MAPK1 P28482 1/20 0.48
TSHR P16473 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8361911 0.90 PDE4B (0.49) PDE4BALDH1A1PKMHTTPDE4A
SCHEMBL8366505 0.88 MEN1 (0.48) PDE4BALDH1A1PKMHTTPDE4A
SCHEMBL8366291 0.87 SMPD1 (0.48) PDE4BALDH1A1HTTPDE4APDE4C
SCHEMBL8359619 0.86 PDE4B (0.60) PDE4BALDH1A1PDE4APDE4CPDE4D
SCHEMBL8359737 0.86 SMPD1 (0.50) PDE4BALDH1A1HTTPDE4APDE4C
SCHEMBL8362145 0.86 SMPD1 (0.50) PDE4BALDH1A1HTTPDE4APDE4C
SCHEMBL8365965 0.86 SMPD1 (0.50) PDE4BALDH1A1HTTPDE4APDE4C
SCHEMBL8359713 0.86 SMPD1 (0.50) PDE4BALDH1A1HTTPDE4APDE4C
SCHEMBL8362314 0.86 SMPD1 (0.50) PDE4BALDH1A1HTTPDE4APDE4C
SCHEMBL8649290 0.86 SMPD1 (0.50) PDE4BALDH1A1HTTPDE4APDE4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999036049-A1 PHOTOSTABLE UV ABSORBENT CONTAINING α-CYANO CINNAMYL MOIETY ISP INVESTMENTS INC. (US) 1999-07-22 WO disclosed