Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.71 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.71 |
| ▸ | CTSD | P07339 | 2/20 | 0.68 |
| ▸ | CTSE | P14091 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363946 | 0.92 | BACE1 (0.74) | BACE1BACE2CTSDCTSE | |
| SCHEMBL4891462 | 0.90 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL3351740 | 0.90 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL4899242 | 0.89 | BACE1 (0.76) | BACE1BACE2CTSD | |
| SCHEMBL5180653 | 0.89 | BACE1 (0.76) | BACE1BACE2CTSD | |
| SCHEMBL5579146 | 0.88 | BACE1 (0.69) | BACE1BACE2CTSD | |
| SCHEMBL3350491 | 0.88 | BACE1 (0.77) | BACE1BACE2CTSDCTSE | |
| SCHEMBL3354515 | 0.88 | BACE1 (0.80) | BACE1BACE2CTSD | |
| SCHEMBL3350500 | 0.88 | BACE1 (0.77) | BACE1BACE2CTSDCTSE | |
| SCHEMBL5367552 | 0.88 | BACE1 (0.69) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003002122-A1 | BETA-HYDROXYAMINE DERIVATIVES USEFUL IN TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-01-09 | — | — | WO | disclosed |