SCHEMBL8365201

SCHEMBL8365201

CCC(C)(CC)c1cc(CCC(=O)O)cc(-n2nc3ccccc3n2)c1O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
POLB P06746 1/20 0.37
MAOB P27338 3/20 0.37
MAOA P21397 2/20 0.37
KEAP1 Q14145 1/20 0.36
GAA P10253 3/20 0.35
FFAR1 O14842 2/20 0.35
LMNA P02545 2/20 0.35
ACHE P22303 1/20 0.35
HDAC6 Q9UBN7 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
TP53 P04637 1/20 0.35
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
PPARG P37231 1/20 0.34
PPARA Q07869 1/20 0.34
RHOA P61586 1/20 0.34
ALDH1A1 P00352 1/20 0.34
AGTR1 P30556 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17254707 0.91 NPC1 (0.38) NPC1RAB9APOLBMAOBMAOA
SCHEMBL29768287 0.90 MAOB (0.45) NPC1RAB9APOLBMAOBMAOA
SCHEMBL100766 0.90 MAOB (0.45) NPC1RAB9APOLBMAOBMAOA
SCHEMBL7692453 0.87 NPC1 (0.38) NPC1RAB9APOLBMAOBMAOA
1,6-Hexanediol SCHEMBL4254054 0.84 MAOB (0.41) NPC1RAB9APOLBMAOBMAOA
SCHEMBL13957896 0.83 GAA (0.41) NPC1RAB9APOLBMAOBMAOA
SCHEMBL466180 0.83 MAOB (0.44) NPC1RAB9APOLBMAOBMAOA
SCHEMBL7593809 0.83 MAOB (0.45) POLBMAOBMAOAGAALMNA
SCHEMBL17238263 0.82 NPC1 (0.42) NPC1RAB9APOLBKEAP1GAA
SCHEMBL8038155 0.82 MAOB (0.43) NPC1RAB9APOLBMAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5900487-A ESTER OF 3-(2H-BENZOTRIAZOL-2-TL)-5-(1,1-DIMETHYLETHYL)-4-HYDROXY BENZENEPROPANOIC ACID GENERAL ELECTRIC COMPANY (US) 1999-05-04 US disclosed