Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 3/20 | 0.57 |
| ▸ | PDE5A | O76074 | 2/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 5/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082386 | 0.90 | ADORA1 (0.62) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL4079175 | 0.81 | ADORA1 (0.65) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL7751035 | 0.81 | ADORA1 (0.65) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL22587451 | 0.81 | ACP1 (0.63) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL7751012 | 0.80 | ADORA1 (0.62) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL22587506 | 0.79 | ACP1 (0.62) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL4077255 | 0.78 | ADORA1 (0.60) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL7752267 | 0.78 | ADORA1 (0.60) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL22587416 | 0.74 | ACP1 (0.60) | ACP1PDE5AADORA1ADORA2AADORA3 | |
| SCHEMBL8366783 | 0.74 | ADORA1 (0.79) | ACP1PDE5AADORA1ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6680324-B2 | 4-AMINO-6-PHENYL-PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2004-01-20 | — | — | US | disclosed |