SCHEMBL8366608

SCHEMBL8366608

CCOC(=O)c1nn(Cc2ccc(C)cc2)c(-c2ccc(Cl)c(C)c2)c1C

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 4/20 0.55
CYP19A1 P11511 7/20 0.51
SMN1; SMN2 Q16637 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
NPC1 O15118 1/20 0.44
LMNA P02545 1/20 0.44
CNR2 P34972 4/20 0.43
MAPT P10636 3/20 0.43
NPSR1 Q6W5P4 2/20 0.43
GAA P10253 1/20 0.43
GPR55 Q9Y2T6 1/20 0.43
HTT P42858 1/20 0.41
GABRA2 P47869 1/20 0.41
GABRB2 P47870 1/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8366630 0.93 CNR1 (0.48) CNR1CYP19A1SMN1; SMN2TDP1LMNA
SCHEMBL8364836 0.87 CNR1 (0.61) CNR1SMN1; SMN2NPC1CNR2MAPT
SCHEMBL8369769 0.87 CNR1 (0.58) CNR1CYP19A1SMN1; SMN2TDP1NPC1
SCHEMBL8369230 0.86 CNR1 (0.57) CNR1SMN1; SMN2NPC1CNR2MAPT
Hydrochloric Acid SCHEMBL8364838 0.86 CNR1 (0.57) CNR1CYP19A1SMN1; SMN2TDP1NPC1
SCHEMBL8366420 0.83 CYP19A1 (0.55) CNR1CYP19A1SMN1; SMN2NPC1LMNA
SCHEMBL8364939 0.79 CNR1 (0.51) CNR1SMN1; SMN2LMNACNR2MAPT
SCHEMBL8364816 0.79 CNR1 (0.53) CNR1SMN1; SMN2LMNACNR2MAPT
SCHEMBL8368098 0.78 CNR1 (0.50) CNR1SMN1; SMN2LMNACNR2MAPT
Hydrochloric Acid SCHEMBL8364818 0.78 CNR1 (0.50) CNR1SMN1; SMN2LMNACNR2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5925768-A ANTIINFLAMMATORY AGENTS; ANALGESICS, ANTICOAGULANTS, NARCOTICS SANOFI (FR) 1999-07-20 US disclosed