Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 0.86 |
| ▸ | EGFR | P00533 | 16/20 | 0.86 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RGS12 | O14924 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366983 | 0.98 | ERBB2 (0.82) | ERBB2EGFRERBB4MEN1RGS12 | |
| SCHEMBL8364532 | 0.96 | ERBB2 (0.79) | ERBB2EGFRERBB4MEN1RGS12 | |
| SCHEMBL8364131 | 0.94 | ERBB2 (0.77) | ERBB2EGFRERBB4MEN1RGS12 | |
| SCHEMBL8364272 | 0.92 | ERBB2 (1.00) | ERBB2EGFR | |
| SCHEMBL8364344 | 0.91 | ERBB2 (0.74) | ERBB2EGFRERBB4MEN1RGS12 | |
| SCHEMBL8367000 | 0.90 | ERBB2 (0.70) | ERBB2EGFRERBB4MEN1RGS12 | |
| SCHEMBL8361237 | 0.90 | ERBB2 (0.70) | ERBB2EGFRERBB4MEN1RGS12 | |
| SCHEMBL8617564 | 0.90 | ERBB2 (0.70) | ERBB2EGFRERBB4MEN1RGS12 | |
| SCHEMBL8366127 | 0.90 | ERBB2 (0.72) | ERBB2EGFRERBB4MEN1RGS12 | |
| SCHEMBL8365822 | 0.89 | ERBB2 (0.70) | ERBB2EGFRERBB4MEN1RGS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |