SCHEMBL8368443

SCHEMBL8368443

CNC(=O)/C(=N\OC)c1ccccc1COc1cccc(Cl)c1

nearest known ligand 0.65

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.65
OPRL1 P41146 1/20 0.45
MAOA P21397 2/20 0.42
MAOB P27338 2/20 0.42
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41
RXRG P48443 1/20 0.41
NR4A2 P43354 2/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
KDM4E B2RXH2 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6451814 1.00 HIF1A (0.65) HIF1AOPRL1MAOAMAOBRXRA
SCHEMBL6451811 1.00 HIF1A (0.65) HIF1AOPRL1MAOAMAOBRXRA
SCHEMBL8369744 0.91 HIF1A (0.59) HIF1AOPRL1HTT
SCHEMBL8369745 0.91 HIF1A (0.59) HIF1AOPRL1HTT
SCHEMBL8368224 0.89 HIF1A (0.66) HIF1AMAOBNPC1RAB9AKDM4E
SCHEMBL8368226 0.89 HIF1A (0.66) HIF1AMAOBNPC1RAB9AKDM4E
SCHEMBL8369615 0.88 HIF1A (0.58) HIF1AOPRL1NPC1RAB9ACYP1A2
SCHEMBL8369616 0.88 HIF1A (0.58) HIF1AOPRL1NPC1RAB9ACYP1A2
SCHEMBL8371621 0.88 HIF1A (0.64) HIF1A
SCHEMBL8399234 0.88 HIF1A (0.64) HIF1AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617011-B1 Process for producing alkoxyiminoacetamide compounds SHIONOGI & CO (JP) 1999-01-20 EP disclosed
US-5506358-A USEFUL AS AGRICULTURAL FUNGICIDES SHIONOGI & CO., LTD. (JP) 1996-04-09 US disclosed
US-5371222-A Intermediates SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) 1994-12-06 US disclosed
EP-0617011-A2 Process for producing alkoxyiminoacetamide compounds SHIONOGI & CO., LTD. (JP) 1994-09-28 EP disclosed