Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28288142 | 0.92 | NR1I2 (0.46) | NR1I2LMNADNM1SLC2A1CSNK1E | |
| SCHEMBL28224807 | 0.89 | NR1I2 (0.44) | NR1I2LMNASLC2A1CSNK1EOPRM1 | |
| SCHEMBL20372803 | 0.88 | NR1I2 (0.37) | NR1I2LMNASLC2A1CSNK1E | |
| SCHEMBL27422072 | 0.88 | NR1I2 (0.37) | NR1I2LMNASLC2A1CSNK1E | |
| SCHEMBL21779330 | 0.87 | MEN1 (0.42) | NR1I2LMNASLC2A1CSNK1ETSHR | |
| SCHEMBL21030358 | 0.87 | MEN1 (0.42) | NR1I2LMNASLC2A1CSNK1ETSHR | |
| SCHEMBL19388156 | 0.87 | MEN1 (0.42) | NR1I2LMNASLC2A1CSNK1ETSHR | |
| SCHEMBL20372927 | 0.85 | NR1I2 (0.36) | NR1I2LMNASLC2A1CSNK1E | |
| SCHEMBL24282360 | 0.84 | NR1I2 (0.35) | NR1I2 | |
| SCHEMBL21024659 | 0.84 | NR1I2 (0.35) | NR1I2DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |