⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20480027 | 0.83 | — | — | |
| SCHEMBL836062 | 0.83 | — | — | |
| SCHEMBL2379470 | 0.83 | — | — | |
| SCHEMBL2378583 | 0.78 | DPP4 (0.30) | — | |
| SCHEMBL2378585 | 0.78 | DPP4 (0.30) | — | |
| SCHEMBL1642178 | 0.76 | — | — | |
| SCHEMBL1114270 | 0.74 | — | — | |
| SCHEMBL1114268 | 0.74 | — | — | |
| SCHEMBL2138253 | 0.74 | — | — | |
| SCHEMBL7939966 | 0.74 | POLB (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143251-B2 | Triazolotriazines as kinase inhibitors | INCYTE CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110144113-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | INCYTE CORPORATION | 2011-06-16 | — | — | US | disclosed |
| US-7915408-B2 | Triazolotriazines as kinase inhibitors | INCYTE CORPORATION (US) | 2011-03-29 | — | — | US | disclosed |