Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SPOP | O43791 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10790206 | 0.86 | TDP1 (0.51) | TDP1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10790200 | 0.86 | TDP1 (0.51) | TDP1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9367257 | 0.78 | CTDSP1 (0.38) | TDP1MAPTALDH1A1HSD17B10KMT2A | |
| SCHEMBL9137559 | 0.77 | NR1I2 (0.44) | TDP1MAPTALDH1A1HSD17B10KMT2A | |
| SCHEMBL9372145 | 0.77 | PTGS1 (0.40) | TDP1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10830929 | 0.76 | PTGS1 (0.40) | TDP1MAPTALDH1A1HPGDNR1I2 | |
| SCHEMBL10830927 | 0.76 | PTGS1 (0.40) | TDP1MAPTALDH1A1HPGDNR1I2 | |
| SCHEMBL9369561 | 0.75 | TDP1 (0.37) | TDP1MAPTKMT2AHPGDNR1I2 | |
| SCHEMBL4809163 | 0.75 | NR1I2 (0.50) | TDP1MAPTALDH1A1HSD17B10KMT2A | |
| SCHEMBL11212601 | 0.75 | NR1I2 (0.50) | TDP1MAPTALDH1A1HSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0495584-B1 | Cephalosporin compounds and their pharmaceutical compositions | LILLY CO ELI (US) | 1999-12-15 | — | — | EP | disclosed |
| US-5637693-A | CEPHALOSPORIN ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1997-06-10 | — | — | US | disclosed |
| US-5362722-A | Antibiotics | ELI LILLY AND COMPANY (US) | 1994-11-08 | — | — | US | disclosed |
| US-5247073-A | Antibiotics for bactericides | ELI LILLY AND COMPANY (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0495584-A2 | Cephalosporin compounds and their pharmaceutical compositions | ELI LILLY AND COMPANY (US) | 1992-07-22 | — | — | EP | disclosed |