Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376712 | 0.83 | HSD17B10 (0.66) | HSD17B10MEN1KMT2ACCNCCDK8 | |
| SCHEMBL22498343 | 0.82 | KMT2A (0.46) | CYP17A1NAMPTMEN1KMT2ACCNC | |
| SCHEMBL29374493 | 0.82 | KMT2A (0.46) | CYP17A1NAMPTMEN1KMT2ACCNC | |
| SCHEMBL29706100 | 0.80 | NAMPT (0.46) | CYP17A1NAMPTSMN1; SMN2KDM4EMETAP1 | |
| SCHEMBL2353760 | 0.80 | NAMPT (0.46) | CYP17A1NAMPTSMN1; SMN2KDM4EMETAP1 | |
| SCHEMBL8375133 | 0.80 | CYP17A1 (0.41) | CYP17A1NAMPTKDM4E | |
| SCHEMBL8376699 | 0.79 | MEN1 (0.46) | HSD17B10MEN1KMT2ACCNCCDK8 | |
| SCHEMBL5777673 | 0.79 | NAMPT (0.45) | CYP17A1NAMPTMETAP1LATS1 | |
| SCHEMBL23674773 | 0.78 | CYP17A1 (0.48) | CYP17A1NAMPTMETAP1LATS1 | |
| SCHEMBL18832828 | 0.77 | NAMPT (0.43) | CYP17A1NAMPTMETAP1LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821239-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE CAUSED BY CHOLINERGIC DEFICIT | FROMMER LAWRENCE & HUAG LLP (US) | 1998-10-13 | — | — | US | claimed |
| US-5869480-A | ALLEVIATING MEMORY DYSFUNCTION CHARACTERIZED BY CHOLINERGIC DEFICIT | HOECHST MARION ROUSSEL INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5866565-A | ALZHEIMER'S DISORDERS | HOECHST MARION ROUSSEL INC. (US) | 1999-02-02 | — | — | US | disclosed |
| US-5821239-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE CAUSED BY CHOLINERGIC DEFICIT | FROMMER LAWRENCE & HUAG LLP (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |