SCHEMBL8375368

SCHEMBL8375368

CNCCCCOCCOC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.40
EPHX1 P07099 1/20 0.39
L3MBTL4 Q8NA19 1/20 0.37
L3MBTL3 Q96JM7 1/20 0.37
CA2 P00918 1/20 0.35
L3MBTL1 Q9Y468 4/20 0.35
SLC6A4 P31645 1/20 0.34
CYP3A4 P08684 3/20 0.33
TSHR P16473 2/20 0.33
HTR1B P28222 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
TP53 P04637 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
LMNA P02545 1/20 0.33
MEN1 O00255 1/20 0.32
THRB P10828 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22882634 1.00 EPHX2 (0.40) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24921953 1.00 EPHX2 (0.40) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24921954 0.98 EPHX1 (0.42) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24922154 0.98 EPHX1 (0.42) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24922157 0.98 EPHX1 (0.42) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24922148 0.98 EPHX1 (0.42) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24922152 0.98 EPHX1 (0.42) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24921933 0.98 EPHX1 (0.42) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24922149 0.98 EPHX1 (0.42) EPHX2EPHX1L3MBTL4L3MBTL3CA2
SCHEMBL24921929 0.98 EPHX1 (0.42) EPHX2EPHX1L3MBTL4L3MBTL3CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024052702-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CAMBRIDGE ENTERPRISE LIMITED (GB) 2024-03-14 WO disclosed
US-20230332145-A1 BIFUNCTIONAL MOLECULES AND METHODS OF USING THEREOF FLAGSHIP PIONEERING, INC. (US) 2023-10-19 US disclosed
WO-2019199816-A1 CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME ARVINAS OPERATIONS, INC. (US) 2019-10-17 WO disclosed
WO-2018144649-A1 CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME Arvinas, Inc. (US) 2018-08-09 WO disclosed
US-9225336-B2 Programmable logic device and semiconductor device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-12-29 US disclosed
US-20150116000-A1 PROGRAMMABLE LOGIC DEVICE AND SEMICONDUCTOR DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-04-30 US disclosed
US-8952723-B2 Programmable logic device and semiconductor device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-02-10 US disclosed
US-20140225644-A1 PROGRAMMABLE LOGIC DEVICE AND SEMICONDUCTOR DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-08-14 US disclosed
US-5986042-A Cross-linked polymer MITSUI CHEMICALS, INC. (JP) 1999-11-16 US disclosed
EP-0856539-A1 Cross-linked polymer Mitsui Chemicals, Inc. (JP) 1998-08-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230332145-A1 BIFUNCTIONAL MOLECULES AND METHODS OF USING THEREOF EFTUD2, DDX21, SNRPE EPHX2 1836/4885EPHX1 4246/4885L3MBTL4 326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.