Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8374707 | 0.99 | PDE5A (0.47) | PDE5AENPP1PDE1BHRH4ACHE | |
| SCHEMBL8374536 | 0.85 | PDE5A (0.50) | PDE5AENPP1PDE1BACHEBACE1 | |
| Hydrochloric Acid SCHEMBL8379494 | 0.82 | PDE5A (0.55) | PDE5AENPP1PDE1BACHEBACE1 | |
| SCHEMBL8378420 | 0.81 | NEK2 (0.53) | PDE5AENPP1PDE1BACHEBACE1 | |
| Hydrochloric Acid SCHEMBL8375179 | 0.81 | PDE5A (0.54) | PDE5AENPP1PDE1BACHEBACE1 | |
| Hydrochloric Acid SCHEMBL8375907 | 0.81 | TLR9 (0.47) | PDE5AENPP1PDE1BACHEBACE1 | |
| SCHEMBL8374694 | 0.81 | KDM4E (0.65) | PDE5AENPP1PDE1BACHEBACE1 | |
| SCHEMBL2920637 | 0.80 | PDE5A (0.52) | PDE5AENPP1PDE1BACHEBACE1 | |
| SCHEMBL8374872 | 0.79 | PDE5A (0.51) | PDE5AENPP1PDE1BACHEBACE1 | |
| Hydrochloric Acid SCHEMBL8375906 | 0.79 | PDE10A (0.64) | PDE5APDE1BACHEBACE1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990117-A | Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives | CELL PATHWAYS, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5614627-A | Quinazoline compounds | EISAI CO., LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0669324-A1 | QUINAZOLINE COMPOUND | Eisai Co., Ltd. (JP) | 1995-08-30 | — | — | EP | disclosed |