Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.68 |
| ▸ | BACE2 | Q9Y5Z0 | 19/20 | 0.68 |
| ▸ | CTSD | P07339 | 18/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578628 | 0.94 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL14625457 | 0.93 | BACE1 (0.72) | BACE1BACE2CTSD | |
| SCHEMBL8380612 | 0.91 | BACE1 (0.67) | BACE1BACE2CTSD | |
| SCHEMBL3576510 | 0.87 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL3579631 | 0.87 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL3572495 | 0.87 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL3573100 | 0.86 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL3575464 | 0.86 | BACE1 (0.67) | BACE1BACE2CTSD | |
| SCHEMBL3573829 | 0.85 | BACE1 (0.69) | BACE1BACE2CTSD | |
| SCHEMBL3568560 | 0.85 | BACE1 (0.71) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417047-B2 | Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation | WYETH (US) | 2008-08-26 | — | — | US | disclosed |
| US-20070004786-A1 | Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004786-A1 | Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation | BACE1, BACE2, APP | BACE1 1/4885BACE2 2/4885CTSD 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.